Dalton later beat Darlington, 60-33, in the title game.
The Rome Lady Wolves' full-court press led to 26 steals for the ninth-ranked team in Class AAAA.
"Rome gets you going at a speed you're not used to," Lady Colonels coach Jamie Horton said. "We've got quite a few guards who have not handled the ball on the varsity level."
Rome exploited that inexperience throughout the game, especially early on when constant swipes of the ball helped the Lady Wolves sprint forward to a 14-0 lead.
Sophomore forward Tamara Leath benefited from Rome's defense, converting on a few runouts to total 8 first-quarter points.
Cass' sophomore center, Carla Clemmons, scored the Lady Colonels' only two baskets of the first quarter as the Lady Wolves led 21-5.
The second quarter began with a similar offensive drought for Cass, with Rome scoring the first 13 points to go ahead by close to 30 before the Lady Colonels notched seven points in the final three-plus minutes of the half to trail 38-12.
Cass again got off to a bad start in the third quarter as Clemmons' three-point play cut the score to 52-15, ending another 14-0 run.
The Lady Colonels were down by more than 40 points -- 60-19 -- heading into the fourth quarter.
With both teams inserting their reserves for much of the last quarter, Cass and Rome combined for just 15 points to bring the final margin.
"Right now we're having a tough time with pressure," Horton said. "We've got to grow up a little bit and learn how to handle that pressure."
Cass's head coach tipped his hat off to the Lady Wolves, but said his team needs to handle the ball better and get it to its weapons.
Clemmons -- who led the Lady Colonels with 12 points, nine rebounds and five steals -- showed some nifty post moves during the game but the game was well out of hand for the 6-footer to do any more damage.
Horton also lamented his team's missed layups -- he estimated something close to 30 -- in the game.
Rome's leading scorer was Leath, who scored 14 points (10 in the first half), while Summer Starr added 11, 13 rebounds, six assists and seven steals and Keri Strucher tallied 10 along with four steals.
In its first four games, including a scrimmage with Stephenson, Cass has played a couple of ranked teams -- the Lady Jaguars (No. 10 in Class AAAAA) and Rome.
"If you're going to get better, you have to play state (ranked) competition," Horton said.
The Lady Colonels (1-2) play at rival Cartersville Saturday.