Ayers was hot from the plate for Cass.
He went 2-for-4, drove in one and scored one run. He singled in the first inning and hit a solo homer in the seventh inning.
Brandon Etheridge, Dylan Williams and Hunter Southern had the other Cass hits.
Tanner Brumby hit a solo home run in the second inning to put the Dragons ahead. They added two more runs in the fourth on a triple by Jesse Decker, an infield error, and an RBI-double by Bryan Morris.
Eric Justice got the win for Pickens.
He allowed two runs over seven innings, struck out nine, walked three and surrendered five hits.
Etheridge suffered the pitching loss for the Colonels. He pitched six innings, gave up five hits, three runs — two of them earned — struck out six and issued three bases on balls.
Pickens evened its season mark at 7-7, and picked up its first region game of the year, making the Dragons 1-4 in 7-AAAA South.
Cass is now 10-6 overall and 3-2 in the region.
The Colonels had won their last three games, including a 7-1 victory over the Dragons at home Tuesday.
The two teams are scheduled to play the rubber game of their three-game series Friday at 5:55 p.m. at Cass High.