The Purple Hurricanes scored two first-quarter touchdowns on Malik Riddick's 61-yard run and Tiamon Pennymon's 47-yard punt return and probably could have led 28-0 if not for a couple of penalties.
Cartersville had a 57-yard punt return by Kalin Heath and a 48-yard run by Pennymon called back because of penalties.
The Canes took a two-score lead into halftime.
When play resumed for the second half, Cartersville exploded for 19 third-quarter points, on Heath's 7-yard run, Trevor Carlton's 37-yard fumble return and Jahir Camps' 12-yard run, which was set up by Mason Heath's 32-yard interception return.
Camps added a 28-yard TD run in the fourth quarter to give the Canes a first-round playoff victory.
Cartersville (7-0) hosts Adairsville in the second round of the region playoffs Thursday at Weinman Stadium. Game time is 4:30 p.m.
SCORING BY QUARTERS
1 2 3 4 F
CAR 14 0 19 6 39
ASH 0 0 0 0 0
CAR -- Malik Riddick 61-yard run (Greg Davis PAT), 6:41
CAR -- Tiamon Pennymon 47-yard punt return (Davis PAT), 3:20
CAR -- Kalin Heath 7-yard run (PAT failed), 5:21
CAR -- Trevor Carlton 37-yard fumble return (Davis PAT), 4:01
CAR -- Jahir Camps 12-yard run (PAT failed)
CAR -- Camps 28-yard run (PAT failed)